![]() The first game established that this Kharra bacteria is so incredibly dangerous that a really advanced alien race feared it so much that they built a giant spaceship-destroying turret to quarantine the planet and could find the only solution to it on a single planet in the galaxy. Plus you have to remember that their bodies are 3/4 cybernetic and can be genetically modified, even taking this "bleach" inside might've not been lethal for them. I feel like if the solution to the Kharra was just airtight biohazard suits that you can just douse in "bleach" and this "bleach" will wipe out the bacteria entirely than the Architects would've somehow managed to synthesize and adapt that system instead of basically going extinct. As far as I remember, in the original game one of the main problems of Kharra was the fact that it's so incredibly infectious. However, I just thought of another problem with this theory. I didn't even think of it myself since in my head "antidote" is specifically a cure, not a disinfectant. I mentioned bleach theory in my other comment, and I agree, it somewhat covers the problem up. Well, there's some wiggle room that maybe Enzyme 42 is that potent, but it just was that long since the last old Sea Emperor secreted it in the waters (how old was she in the original game, like millennia old?) that it cleared out of the planet's ecosystem, but I agree, that's why I said that such an assumption is kind of dumb. In any case, it's a failure on devs part to cover this plot hole with in-game canonical lore properly and making us cover it up with other assumptions without any proof, yeah. However, that requires an assumption that devs don't know the difference between "antidote" and "bactericide", used the wrong term in multiple places of the game and nobody on the team thought to correct it once. ![]() So pretty good theory to cover this plot hole. That would make it easy to create out of random things even for a person without special education and would make it not reliant on Enzyme 42, since it's not the cure. There is another theory someone mentioned in other threads: that "antidote" is not actually a cure, just a bactericide like bleach, so it would work only as a disinfectant on a dead body, but would kill a living one. but it's alien planet, why the hell not xD Well, it would make Enzyme 42 an incredibly weird magical substance that can infiltrate without dissolving basically any other organism and stay in it without doing any harm to the organism whatsoever for a very long period of time without being ejected. And if we don't make any assumptions, then yeah, it even screws up the story of the first game, since then Enzyme 42 is not necessary for a cure of some strands of Kharra, which means that it might be not necessary for a cure of the original strand of Kharra as well. ![]() So yeah, you can somewhat cover this if you do developers' job for them and make some assumptions, but even then it makes no sense in the end. This is an actual plot hole: Even if we take the assumption above as correct (which is a massive IF, since I feel that it's kind of dumb, just playing devil's advocate), there is no way that a human robotic engineer can have enough knowledge in biochemistry to actually realize this assumption and slap together a cure out of random plants, which would be exactly right for that exact Kharra mutation type, and potent enough to cure that whole giant corpse. Which, if true, still makes the cure of any Kharra reliant on Enzyme 42, and so leaves the first game story intact. Which is why basically a couple of any plants can possibly be used to synthesize a cure for Kharra. ![]() This is an assumption to cover the plot hole: Since Enzyme 42 is released into the eco-system, it entered the water cycle in nature and basically some part of Enzyme 42 is now contained within every plant that feed of that water and every animal that drank that water. So it's not "an alternative cure", it's another cure for another strand. That's why it requires a new antidote, not simply Enzyme 42, as the original strand. This is stated in canon: When you scan Kharra pustules on the Frozen Leviathan, the result mentions that this corpse contains a mutated Kharra strand, which adapted to living off dead cells.
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